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CAS 1953-04-4 Galanthamine Hydrobromide Nootropics Powder Alzheimer'S Disease

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CAS 1953-04-4 Galanthamine Hydrobromide Nootropics Powder Alzheimer'S Disease

Brand Name : Hongkong SaiChuang
Model Number : 616204-22-9
Certification : ISO9001
Place of Origin : China
MOQ : 10g
Price : negotiable USD
Payment Terms : Western Union, L/C, , D/A, MoneyGram, T/T, D/P
Supply Ability : 1000KG/month
Delivery Time : within 12 hours after payment
Packaging Details : safe discreet package
Origin : ZheJiang
Name : Galanthamine Hydrobromide
WhatsApp : +86 18873303856
Email : majorina.cai@chembj.com
Tel : +86 18873303856
MF : C17H22BrNO3
MW : 368.27
Purity : 99%
Appearance : White crystalline powder
Packaging : discreet packaging
CAS : 1953-04-4
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Galanthamine Hydrobromide Nootropics Powder Alzheimer's disease Treatment CAS:1953-04-4

Basic INFORMATION

Product Name: Galantamine Hydrobromide Lycoremine
Botanical Name: Lycoris Radiata (L'Herit)
Specification: Galanthamine: 98%-99%
Test method: HPLC
CAS No. : 1953-04-4
Molecular Formula C17H22BrNO3
Molecular Weight: 368.27
Appearance: White crystalline powder

Structural Formula:


What is Galanthamine Hydrobromide ?

Galantamine is an alkaloid originally found in species of Galanthus, Narcissus, Leucojum, and Lycoris; it exhibits neuroprotective and cognition enhancing activities. Galantamine inhibits acetylcholinesterase (AChE) and acts as an allosteric agonist on nicotinic acetylcholine receptors (nAChRs) and muscarinic acetylcholine receptors (mAChRs); it is somewhat selective for α7 nAChRs. Galantamine is clinically used to improve cognitive deficits in subjects with Alzheimer’s disease. Galantamine is neuroprotective and promotes neurogenesis in an IGF-2-dependent manner. Galantamine may also inhibit P2X7 receptors, increasing Bcl-2 expression and inhibiting apoptosis.


Mechanism of action of galantamine hydrobromide

So how exactly does galantamine hydrobromide work? Although the act of cognitive impairment in Alzheimer’s (AD) isn’t fully understood, it’s been reported that acetylcholine-creating nerves degenerate within the brains of patients with Alzheimer’s. The degree of this cholinergic loss continues to be correlated with amount of cognitive impairment and density of amyloid plaques (a neuropathological hallmark of Alzheimer’s).
Galantamine hydrobromide binds electrostatically towards the enzyme active site of cholinesterase. Binding is reversible, as a result it functions as a competitive reversible inhibitor of cholinesterase and extends the hydrolysis of endogenous acetylcholine, therefore growing its accumulation and extending and potentiating its effects, that are expressed in intensified and prolonged mediation at the amount of cholinergic postsynaptic membrane. Galantamine hydrobromide has been discovered to exert direct impact on some CNS structures with cholinergic nerves. Additionally, it functions in CNS by reflex path, potentiating afferent impulses from some peripheral reflexogenic areas.


COA of the Galanthamine Hydrobromide
Items of analysisSpecificationResults
AppearenceWhite crystalline powderWhite crystalline powder
IdentificationIR HPLCComplies
Test for BromideA yellow precipitate is formed indicating the presence of bromideions.Complies
Loss on Drying (%w/w,determined on 1.0g)Not more than 0.5%0.25%
Residue on Ignition (%w/w,determined on 1.0g)Not more than 0.1%0.06%
SolubilitySoluble in 0.1N sodium hydroxide, sparingly soluble in water, very slightlyComplies
Heavy metalsNot more than 20 PPMLess than 20 PPM
Limit Of Galanthamine Enantiomer [(+)-Galanthamine] (By HPLC,%w/w)Not more than 0.01%Not detected
Norgalanthamine [USP:N-Desmethylgalantamine]Not more than 0.20%Not detected
Lycoramine[USP:Dihydrogalantamine]Not more than 0.35%0.13%
Glanthamine N-oxideNot more than 0.20%Below Limit of Quantification
EpigalanthamineNot more than 0.40%Below Limit of Quantification
O-DesmethylgalanthamineNot more than 0.20%Not detected
NarwedineNot more than 0.15%0.02%
Any otherNot more than 0.10%Not detected
TotalNot more than 1.0%0.17%
Assay98.0-102.0%99.77%
TolueneNot more than 890 ppmBelow Limit of Quantification
EthanolNot more than 5000 ppm377ppm
TetrahydrofuranNot more than 500 ppmNot detected
Bromide ContentBetween 20.6 %and 22.8%21.70%
Particle Size(By Malvern Particle size analyzer, µm)D(v,0.1)29 µm
ConculsionThe results can conform to USP30 Standard

Function

(1) Anti-cholinesterase .

(2) Stimulate and inhibit acetylcholinesterase, regulate intracephalic nicotine receptor position.

(3) Cures the infantile paralysis sequelae, sweeny and myasthenia gravis pseudoparalytica, etc.

(4) Improve the recognition function of light, mild Alzheimer disease patients significantly, and delay the process of function decrease of brain cells.

(5) Improve the conduction between nerve and muscle.

Application:


1. Galanthamine Hydrobromide is mainly used in myasthenia gravis, poliovirus quiescent stage and sequela, also in polyneuritis, funiculitis and sensorimotor barrier caused by nervous system disease or traumatism.


2. Galanthamine Hydrobromide is also used in Alzheimer's disease, has the principal function for dement and dysmnesia caused by organic brain damage.


Side Effects

The side effects of galantamine hydrochloride may be very uncomfortable, and mainly contain vomiting(throwing up) and nausea(sickness). Modifying the patient’s diet might help mitigate these effects. The seriousness of the adverse effects and also the small amount of improvement has brought some doctors to summarize that anticholinesterase treatments are not warranted. Current types of pathology concentrate on the beta amyloid plaques that form within the brain.


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